nlwxpearo
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 Posted: Wed 11:18, 16 Mar 2011 Post subject: Advances in immunosuppressive treatment of renal d |
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Advances in immunosuppressive treatment of renal disease
[6] MorelD. mTORandFRY720inhibitors [J]. PresseMed, 2001,30 (1) :35-37. [7] DanielC, ZiswilerR, FreyB, eta /. ProinflamnmtoryeffectinexperimentalmesangialproliferativeglomerulonephritisoftheimmunosuppressiveagentSDZ-RAD, arapamycinderivative [JJ. ExpNephrol, 2000,8 (1) :52-62. [8] VincentiF, KirkmanR, LightS, eta /. Interleukin-2-receptorblockadewithdaclizumabtopreventacuterejectioninrenaltransplantation [J]. NEnglJMed, 1998,338 (1) :161-165. [9] BohlerT, WaiserJ, SchutzM, eta /. Woodlands' Y7amediatesreductionoflymphocytecountsinhumanrenalanos ~ ftrecipientsbyanapoptosis-independentmechanism [J]. Transpllnt, 2OOO,[link widoczny dla zalogowanych], 13 (SupplI) :311-313. Angiotensinogen gene and essential hypertension Hui Ye, Wang Daowen (Huazhong University of Science Tongji Hospital, Tongji Medical College, Cardiovascular Research and Gene Therapy Center, Wuhan 430030) [Abstract] angiotensinogen (AGT) gene in two Variant M235T,[link widoczny dla zalogowanych], T174M is associated with essential hypertension, AGT gene polymorphism on the renin - angiotensin system have a certain role, AGT gene transcription of some variation on the level of AGT, renin substrate catalytic angiotensin converting enzyme activity and the role of greater impact, thus affecting the angiotensin levels have an effect on blood pressure. [Key words] angiotensin; hypertension, primary [CLC] R971; R541.3 [Document code] A [Article ID] 1004-0781 (2002) 09-0537-01 primary high blood pressure (EH) is a common disease, often associated with more serious cardiovascular and cerebrovascular disease, statistics of disease incidence in 1991 reached 13.6%, compared with 1980 increased by about 25% uJ. Hypertension is not clear because of its reasons, so the poor treatment _2j. EH has been found that some genes with the pathogenesis and has become the research hotspot in recent years, suggesting that EH have a certain relationship with genetic disease. First, EH was found with the genes - angiotensinogen (AGT) gene, is more in-depth study, and the more important of the EH gene J. 1AGT its gene renin substrate AGT is, the Department of a glycoprotein,[link widoczny dla zalogowanych], in its amino terminus [Received Et period] 2001.07.12 【Author] Ye Hui (1964 a), male, Zaozhuang, the Deputy Director, MD, PhD,[link widoczny dla zalogowanych], is mainly engaged in studying cardiovascular diseases. Angiotensin workers, human plasma AGT is a le a globulin, by the 453 amino acids, due to different levels of glycosylated molecular weight of 62,000 to 6.5 million, mainly synthesized by the liver and released into the blood, in normal concentration in human plasma 1tmaol · L-, renin and angiotensin converting enzyme in the role, the formation of angiotensin Ⅱ. Angiotensin Ⅱ and its receptor produces a variety of biological effects, leading to increased vascular resistance, cardiac output increased, and stimulate aldosterone release cause sodium and water retention, so that the blood pressure, now that the renin. Angiotensin system in the pathogenesis of EH plays an important role in J. Angiotensin primordia because a single copy gene mapping of different species of different, but very similar to the encoding AGT, the human AGT gene located on chromosome 1q42 ~, AGT gene is from 5 exons and 4 introns The 13kb genomic sequence, exon 2 encoding amino acids 59% AGT, exon 5 791 bp from the composition, may contain polyadenylation signal,[link widoczny dla zalogowanych], and encoding 62 amino acids and 3 non-
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