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 Posted: Wed 15:45, 02 Mar 2011 Post subject: Antiphospholipid antibody syndrome, the mechanism |
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,[link widoczny dla zalogowanych]
Antiphospholipid antibody syndrome, the mechanism of thrombosis
. Cause placental thrombosis and spontaneous abortion,[link widoczny dla zalogowanych], although the reported existence of some cases of decidual and placental infarction pathology. But not all cases are so, so deep research remains to be further antiphospholipid syndrome immunopathogenesis Zhang Yuan Chao Yang Qingrui (Qilu Hospital of Shandong University, 250012, China) are widely present in plants and animals in the phospholipids. The largest number of ancient human body lipid composition. P l fat is the major biochemical components of the biofilm. Maintenance of cell and organelle structure and function intact. Phospholipid polar structure inward state. Non-polar side out. No antigenicity. Maintain the state phospholipid blood free the nervous system, reproductive system, reticuloendothelial system, the physiological function of the coagulation system. Free state phospholipid and plasma protein binding. Was immune paralysis. The amount of leakage of the physiological structure of phospholipid antibodies may be combined. Quickly cleared. In the past with the phospholipids by extraction of raw materials into PC and PE. Is now clear that the two phospholipids are mixtures of different phospholipid monomer; biofilm containing a variety of electrical components = phospholipid monomer in theory, can become self-antigen or hapten may have many types of phospholipids, but has been used clinically a 5 ~ l0 of the most common detection of anticardiolipin antibodies for diagnosis of antiphospholipid syndrome (APS), the nervous system-specific phospholipase is not included. Phospholipid antigen recognition and autoimmunity start is still unclear. As a non-homogeneous phospholipid complex, so complex antigenic characteristics and tripod shown clearly with the controversial single antigen is a two phosphatidyl glycerol (- phosphate Gan pumping, heart phospholipids), phosphatidylcholine (egg phospholipids), phosphatidyl inositol (phosphatidylinositol peptide) is a non-antigenic phosphatidylethanolamine (lysolecithin), phosphatidylserine (brain phospholipids). ① diphosphoglycerate online granulocyte cell membrane solid color tangled c chain. Extract more from the calf myocardial cells, immune globulin can be identified because of the acid anion end units can occur with non-immunoglobulin binding ionic recognition, increased use of titer, fork with other ionic phospholipid antibody binding. False positive reaction occurred. So the detection of the absorbance value of x ± 1Os before OD is a highly positive. This is a unique anti-cardiolipin antibodies. ◎ phosphatidylinositol and the peptide antigen @ end table with MCPC603 phosphorylcholine in mice with combined features of X-lgAFab segment crystal diffraction analysis shown in Table 1 (Padlan.1976 years) ④ no antigenicity of two phospholipid and sugar by protein-1 (Island GP-1) binding with the antigen. There are also units of the protein antigen of the phospholipid binding. The plasma concentration 2Og/ml, also known as apolipoprotein H, molecular weight of 50,000, the ancient 326 AA, and phospholipid binding function in the Fifth District lys28 Pu 288, while often associated with an increase in heat shock protein APS has almost all the primary GP-1 antibodies increased. No antigen in the diagnosis of antiphospholipid syndrome phospholipase more meaningful. The same as the phospholipid cofactor, showed high titer antibodies, known as the first antibody with the antiphospholipid syndrome cofactor. @ With the phospholipid binding antibodies lgG, M, AlgG more than lgM pathological significance. B lymphoid have some relevant germline mutations in the variable region, C allele defects. A Ⅱ, APC in MHC DRB1, 08 Xiu / I) QA】, 0】 031DR7, DR6, r) Qw7, 8,9 increased. Studies have shown that. CD1 lipid antigen presentation and related molecules. Table I phosphorylcholine in mice with the MCPC platform features lgAFab section Results of x-ray crystallography diffraction antiphospholipid antibodies (API) can cause elevated anti-phospholipid syndrome. Also involved in the blood,[link widoczny dla zalogowanych], breathing, the more feces, nervous,[link widoczny dla zalogowanych], gynecological, pediatric diseases and other pathological mechanism of injury was; (DAPL t vascular endothelial vascular endothelial cells to release prostacyclin reduced vasoconstriction. Platelet aggregation. Intravascular v · w factor, the organization due to the increase. easy-to micro-injury thrombosis after endothelial antibody binding. the damage progress in increasing ② API, the body out, the mechanism of blood coagulation: API is a heterogeneous group of antibodies,[link widoczny dla zalogowanych], which can affect the clotting mechanism of many part of the API of people began lupus anticoagulant (IA). LA is a group of immune globulin. interference in vitro and extend a variety of phospholipid dependent coagulation tests. LA contains live enzymes anti-thrombin complex before phospholipase antibodies. thrombin activity before interference with a complex interaction between thrombin; in the body IA and thrombosis. coagulation factor - coagulation activity depends on the fat part of the Lou, of which the most important ester phosphatidyl ethanol. In II】 I participation. API combined with the factor Ⅲ. promote the extrinsic coagulation activation diameter arrest. hypercoagulable state so that the body is. APL and endothelial cells have the negatively charged sulfate acid liver orderly response function of APL can change ATl thrombosis Cijiesuoxiang 51
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