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Enkephalin enhanced neurotrophic effect of glial cells and the reduced NO generation


ispdcellculture. Delete n ship,[link widoczny dla zalogowanych], l977, l26: 397 ~ 425. [12] knife laIlgYP (Zhang Yanping) Con, el ~ ienassociatedn1t-50 (GAP-43) -, ~ thneuralrege. 1l ~ ation and ndde. . 'EloNnem. Bask: Meal (Basic & Clinical Medicine),[link widoczny dla zalogowanych], 1994,14 (1): 23 ~ 26 (inCA.in ~ e-, Yi ~ Er5Ilabstract). [13] IgBrasI1; M, Li, SudoY, tig. nd-lndu,: ~ c knock eeallal: ~ e: amplification and the ndb 【nosebleed hbyV at riG & P-43pe called d cool Jm1995,[link widoczny dla zalogowanych], 15 {: 566O ~ 5667. [14] wangAJ (King of the King), YmagYz (Yang Yu Jin), wuYM (Wuyuan Ming) Effectof Xiu 'bleed at the nose r state bleed at the nose of the keph convex 1inoIIeellul ~ immunefur ~ efionaT1dbL Ⅱ, lBgeneexpressioninmtmPhy ~' M Song (Physiology),[link widoczny dla zalogowanych], 1996,48 (4) :348-354 (inChinesetl1Englisht) cylinder _o2i ∞ threat Mengle Jun1999,[link widoczny dla zalogowanych], 51 (3), 327 ~ 332EFFECToFE] Figure IAIJoNGI, IAI. NEURoTRo squirt CFUNCTII) NRELATEDTO. 1 EREDUCT0NoF Ⅱ TRIC0X1I) EPRoDUCT0NWEIGgANG-WgI, DU. NA, ZHUC0c, TANGCHONC-~. cA0) 【IAc, WUGCHENc ¨ (State Research LaboratoryMed / ca / Neun ~, / o / ogy, D ore Neurob / o / o ~ y, gMed / e ~ Uniters time, g2011032) ABSI. ACl. Theeffectofmethionine-enkephalin (ME) O13alneuro [ropl ~ efunctionwasstudiedinratcorticalgHal-nellron ~. 1eoeul ~ re. TheresultsshowedthatME-treatedgliaenhancedneuronalsurvivalby28% (P <0.05), andincreasedtotalneuritelengthpermnbyl1% (P <0.o5), whiletheexpressionofGAP-43mRNAby26% (P <0.05). TheeffectofMEonNOproductionofgliawasalsostudiedinratcorticalgHalculture. Theresultsho ~ edthatdifferentc0ncentrationsofME (10 a, lO 一 0, lO a. ,10-6mol / L) inhibitedglialNOproduction. AlltheaboveshowthattheincreaseofelialneumtmphicabilitybyMEmaybeduetotheinhibitionofelia1NOproduction. Keywords: rnethionine-enkeph ~ in; ial-neuronaleoeulture; GAP-43; NOSupportedhtheI3 ~ etofialFc ~ ien0fNationalEducationc0nmtLee0fClaim (No9506197) and r-dNationalNatm-alScienceF [. 1IIdadoIIofCNm (No.39730510) \