nlwxpearo
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 Posted: Wed 0:52, 09 Mar 2011 Post subject: Fluorescence absorption test in early syphilis and |
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Fluorescence absorption test in early syphilis and congenital syphilis diagnosis of syphilis
Leukemia, 3 cases of hepatitis B patients, 3 were pregnant women; 82 normal physical examination are among the 2 false positive. 88 cases of syphilis RPR false negative in 15 cases, 5 cases of primary syphilis, 9 cases of congenital syphilis, and only 1 case of tertiary syphilis. Because there is a certain RPR false positive and false negative, only as a screening test. TPHA and FTA-ABS is specific serum antibodies. TPHA is sonication of Treponema pallidum as the antigen,[link widoczny dla zalogowanych], sensitized sheep red blood cells, or poultry. The red blood cells and anti-TP antibodies encounter can produce visible agglutination. Are reported in the literature. Measured in 9 cases of early syphilis. TPHA-positive, only 4 cases, 5 cases were false negative. This study, 31 cases of primary syphilis, 4 false negatives, 16 cases of congenital syphilis and 6 false negatives. Description TPHA of early syphilis and congenital syphilis is less sensitive. The reason may be due to TPHA directly dependent on the operator to judge the results with the naked eye, and early syphilis,[link widoczny dla zalogowanych], patients with low levels of antibodies, antigen-antibody reaction is weak, resulting agglutination difficult to observe the naked eye. The fluorescent treponemal antibody absorption test (A-ABS) is based on Reiter strains of Treponema absorb the tested serum, which can distinguish between TP and other non-pathogenic spirochetes, to ensure the specificity of the test result to the whole of Treponema pallidum in serum antibody, to improve the sensitivity of the test, the FTA-ABS diagnosis of syphilis is considered the Data shows that the specificity of primary syphilis, FTA-ABS97% (94% ~ 100%), TPHA99% (98% ~ 99%); sensitivity of FTA-ABS84% (70% ~ 100%), TPHA76 % (69% -90%). That the specificity of the two basic experiment is similar to syphilis,[link widoczny dla zalogowanych], but the sensitivity of FTA-ABS than TPHA. This study also showed,[link widoczny dla zalogowanych], FTA-ABS and TPHA similar specificity were 100% and 98.1%, higher than the RPR (P 0.05). The results suggest that FTA-ABS of early syphilis and congenital syphilis have a high diagnostic value. This study, 31 cases of primary syphilis,[link widoczny dla zalogowanych], FTA-ABS all positive, TPHA, 4 cases were negative, RPR negative in 5 cases, days or weeks after the review of these patients, TPHA and RPR were converted to positive; 16 cases of congenital syphilis in, Fq'A-ABS positive and negative in 4 patients TPHA, RPR 7 cases, all diagnosed as syphilis eventually. In our view, especially when early syphilis and TPHA negative, RPR, FTA-ABS has high clinical value. The foregoing analysis, FTA-ABS is a diagnosis of early syphilis and congenital syphilis was a sensitive indicator, it is widely applied in clinical diagnosis.
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