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 Posted: Wed 15:19, 09 Mar 2011 Post subject: scarpe nike 2011 Familial adenomatous polyposis Ag |
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Familial adenomatous polyposis AgNOR and Detection of estrogen receptor
Receptor (ER) detection of rare domestic and foreign reports, the experimental lesion of the various stages of FAP fAgNOR count, shape measurement and detection of ER in order to investigate the clinical significance of the change. Materials and methods collected in our hospital since 1984, and the accumulation of Tongji Medical University Hospital FAP samples, select a different phase of the adenoma group lesions observed. Roughly divided into 3 groups, namely, flat mucosa group, 0.5cm The following adenomas, lcm or more adenomas: endoscopic morphology divided into 5 groups, namely, no significant proliferation of flat mucosa group. A flat film revolves dysplasia (micro-adenoma group),[link widoczny dla zalogowanych], I ~ Ⅱ grade dysplastic adenomas, Ⅲ grade dysplasia adenomas,[link widoczny dla zalogowanych], carcinoma group: 20 patients with selected lesions in each group. Another 20 cases of normal colorectal mucosa and 2O observed as control samples. Slices in the oil microscope silver staining 100 cells were counted and measured the mean AgNOR granule cells in the maximum diameter of 100 mean, of particle shape and be shaped particles (ie,[link widoczny dla zalogowanych], giant blocks,[link widoczny dla zalogowanych], a variety of irregular shapes, dust-like particles) count ER Affinity selection marker staining: positive conclusion: positive cells of 2O for the positive cases, chi-square statistical checking method used. The results of a, AgNOR counting and diameter measurement,[link widoczny dla zalogowanych], morphological observation of normal mucosa group and no significant proliferation of mucosal FAP group, the number of silver-staining particles were less in the two particles are small and round, with a median common, no significant difference between the two groups ; FAP FAP microadenomas mucosa group and group differences were statistically significant (P <O.05). FAP microadenomas group and the eyes see, the number of particles of different sizes adenomas more than 3 more than in the two groups was no significant difference in I ~ ll grade dysplastic adenoma and adenoma grade Ⅲ were significantly different (P < 0.05); carcinoma group but lower than that of grade Ⅲ adenoma count, but the difference was not significant, the former special-shaped particle counts were significantly increased. Diameter, with the latter difference was statistically significant (P <0.O1, P <0.001) o Second, ER detected: 20 cases of normal colorectal mucosa ER-positive in 2 cases, 20 cases of non-FAP colorectal cancer 5 cases of ER-positive group, while the FAP mucosa and different degrees of dysplasia in adenomas, cancer organizations have to find positive lesions. Discuss the results showed the formation of adenomas in FAP the naked eye in many regions of the performance of endoscopic mucosal change microadenomas AgNOR count was significantly higher than the proliferation of non-FAP mucosa and normal mucosa, and 0.5cin below and above 1cm no significant difference in adenoma, indicating that FAP whether in early or advanced disease, the cell proliferation than active. Currently, many reported the silver staining of colorectal cancer than benign particle counting. That the AgNOR count is to determine the large intestine benign and malignant lesions of the valuable indicators. And we observed, FAP polyps with cellular atypia increased level of increase, when the cancer tended to decrease in number after. This study suggests that silver staining alone to determine the particle count of colorectal benign and malignant lesions is not objective. Benign changes in various stages of the cell cycle is relatively stable, its decomposition and fusion edge kernel dynamic relative equilibrium, although the number of AgNOR particles increased, but the size and shape of the particles showed a more rules. The dynamics of cell cycle control and malignant lesions, often show two characteristics: First, nucleolar fusion defect of fine dust-like particles: the second is the integration of hyperthyroidism, so that gathered into coarse particles agglomerate. The two shaped particle counting and diameter measurement on the diagnosis of malignant tumors have a more important significance. In this study, the ER of FAP testing, 1 case was found positive, while colorectal cancer and normal mucosa were detected positive cases. We believe that FAP is not associated with estrogen is a genetic variant of its genes, Erisman ... confirmed that FAP gene in colorectal cancer gene package Kyrgyzstan, the cancer rate. The other primary colorectal cancer is a variety of factors beta I synergy, some of which related to estrogen. On both the treatment and prognosis is also worth further exploration.
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