nlwxpearo
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 Posted: Fri 21:47, 11 Feb 2011 Post subject: Synthesis of Tetrahydropyridinyltriazolothiadiazin |
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Synthesis of Tetrahydropyridinyltriazolothiadiazines as Possible Muscarinic Agonists
N21.74.6a: yield72%, mp174 ~ l76 ℃. IR (KBr) v: 3345, l6l7, l557, l264cm: HNMR (DMSO. .6 ppm). -8.16 ~ 7.82 (m, 5H, Ph-H), 6.8l (d, 2H, J - 3.2Hz, H a 4), 4.08 (s, 2H, CH2), 3 .37 (brs, 2H, H a 2 '), 2.86 ~ 2.66 (m, 3H, H a 6andOH), 2.53 (brs, 2H, H a 5'): EIS-MS (70eV) m / z: 314 (M + H). Ana1. (Calcd.forClH1NOS): C57.49, H4.82, N22.35: Found: C57.6l, H4.55, N22_31.6b: yield63%, mpl68-170 ℃. IR (KBr) v: 3362, l624, l602, l265cm: HNMR (DMSO one, 6ppm). '8 .04 ~ 7.63 (m, 4H, Ph-H), 6.72 (d, 2H,[link widoczny dla zalogowanych], J = 3.6Hz, H a 4), 4.12 (s, 2H, CH2), 3. 96 (s, 3H, CHO), 3.37 (brs, 2H, H a 2), 2.84 ~ 2.72 (m, 3H, H a 6andOH), 2.55 (brs, 2H, H a 5 ); EIS-MS (70ev) m / z: 344 (M + H). Ana1. (Calcd.forC16H17N5O, S): C55.96, H4.99, N20.39; Found: C56.12. H4.87. N20.43.6c: yield48%, mp152 ~ l53 ℃. IR (KBr) v: 34l7, l606, l585, l266cm: HNMR (DMS0 one, 6ppm): 7.87 ~ 7-34 (m, 4H, Ph-H), 6.68 (d, 2H, J = 3 .6 Hz, H a 4), 4.17 (s, 2H, CH2), 3.35 (brs,, 2H, H a 2), 3.15 ~ 2.74 (m, 3H. H a 6andOH), 2.55 (brs, 2H, H a 5), 2.43 (s, 3H,[link widoczny dla zalogowanych], CH1): EIS-MS (70eV) m / z: 328 (M + H). Ana1. (Calcd.forCl6H17NOS): C58.70, H5_23, N21.39; Found: C58.82. H5.26. N21.44.6d: yield35%, mpl60 ~ l62 ℃. IR (KBr) v: 3437, l624, l557, l265cm: HNMR (DMSO one, 6ppm) :8.26-7 .53 (itl, 4H, Ph-H), 7.03 (d, J - 3. 5Hz,[link widoczny dla zalogowanych], 2H, H a 4), 4.21 (s, 2H, CH2), 3.35 (brs, 2H, H a 2), 2.87 ~ 2.68 (m, 3H,[link widoczny dla zalogowanych], H a 6andOH), 2.53 (brs, 2H, H a 5): EIS-MS (70eV) m / z: 348 (M + H). Ana1. (Calcd.forClH14ClNOS): C51.80, H4.06, N20.13: Found: C51.88, H4_32, N20_32.6e: yieldl7%, mp188 ~ 190 ℃. IR (KBr) v: 3345, l6l7, l485, l264cm: HNMR (DMS0 one, 6ppm) 8.17-7.82 (itl, 4H, Ph-H), 6.74 (d, 2H, J = 3Hz, H-4), 4.15 (s, 2H, CH2), 3.43 (brs, 2H, H a 2),[link widoczny dla zalogowanych], 2.85 ~ 2.63 (m, 3H, H a 6andOH), 2.55 ( brs, H, H a 5): EIS. MS (70eV) m / z: 359 (M + H). Ana1. (Calcd.forClH14N03S): C50.27, H3.94, N23.45: Found: C50.4l, H4.12.48, N23.60. Received18Novembe ~ 2003
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