nlwxpearo
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Location: England
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 Posted: Sat 22:32, 19 Mar 2011 Post subject: The efficacy of misoprostol in preventing postpart |
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The efficacy of misoprostol in preventing postpartum hemorrhage observed
150 cases of mothers giving birth in our hospital were randomly divided into two groups and the control group, 79 cases in which the observation group, 71 patients in control group were given misoprostol and in the postpartum oxytocin, postpartum hemorrhage were detected, and the comparison. Results The average amount of vaginal bleeding after childbirth 2h observation group (162 ± 42) ml, control group (254-4-37) ml, the two groups was statistically significant (P 0.05). 3 to discuss the synthesis of prostaglandin E1 misoprostol is a derivative. In recent years, find it with the body's own secretion of prostaglandins, almost involving all kinds of important physiological activities of the body, and its most important role and practical application is to control reproduction and childbirth, the uterus during pregnancy were each contraction ,[link widoczny dla zalogowanych], especially the most sensitive to the uterus in late pregnancy J, it has a rapid oral absorption, quick, efficient, 15min in the plasma levels of active metabolite misoprostol acid peak, has been widely used in the induction of labor in late pregnancy and the uterus bleeding caused by atony, after oral administration can be converted into the active misoprostol acid, strong uterine smooth muscle contraction,[link widoczny dla zalogowanych], promoting rapid closure of uterine sinuses. Has been of postpartum hemorrhage is common obstetric complications, leading to an important cause of maternal death. In the leading factors of postpartum hemorrhage, uterine atony is more rare, prolonged labor, large children, twins, polyhydramnios, placenta previa, severe preeclampsia can often be due to excessive expansion of the uterus,[link widoczny dla zalogowanych], uterine over-stretched muscle fibers uterine muscle edema,[link widoczny dla zalogowanych], oozing, affecting the normal uterine contractions and the role of reduced re-J. In addition,[link widoczny dla zalogowanych], in some high-risk mothers, the sedative, antispasmodic, and the application of antihypertensive drugs can cause different degrees of uterine muscle relaxation, so that significantly higher rates of postpartum hemorrhage due to misoprostol in these high-risk reduction of maternal postpartum 2h blood loss, indicating that the drug is a simple, safe and effective drugs to prevent postpartum hemorrhage, reducing maternal mortality has important practical significance.
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