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PostPosted: Wed 1:30, 23 Mar 2011    Post subject: timberland portugal _2016 endocrine therapy for br

Endocrine therapy for breast cancer


To endocrine therapy is too simple, too easy, so that doctors and patients are reluctant to believe that endocrine therapy in practice without careful observation of response to endocrine therapy, but not seriously evaluate their results. Over time a vicious circle,[link widoczny dla zalogowanych], resulting in recurrent and metastatic lesions not everyone endocrine therapy alone; even if you do, is unprincipled, unplanned reactor together with the use of chemotherapy. On the contrary, after radical surgery, disease-free status of the patient, regardless of whether the patient is ER (+), regardless of whether the patient is suitable for endocrine therapy in chemotherapy plus TAM. These practices not only the drug-consuming resources and medical costs, but also to the patient to unnecessary adverse reactions; the majority of breast cancer patients, particularly ER (+) patients had a lower cost of waste, less toxic, better effect of treatment. In order to truly play the role of endocrine therapy for breast cancer, we should do the following: ① first thought to believe in the ER (+) patients with recurrence and metastasis, is the exact effect of endocrine therapy, in which the initial treatment were better. ② In clinical practice, should be carefully observed endocrine therapy for each patient's disease evolution, a careful analysis of their symptoms, including bone metastases, and all tumor lesions, including the objective test results: This is the correct implementation of the endocrine therapy key elements. ③ Do not endocrine therapy combined with chemotherapy, the two combined did not improve efficacy, but the evaluation of interference effects, the follow-up treatment at a loss. ① The recurrence patients, should not be the first local excision or local radiotherapy. Can not be resolved because of local treatment of patients with advanced systemic spread of the subclinical lesions, but should do first body (724 patients), _ *. '. _ ¨ _ll ¨ '-III】. ''FilI. _H ¨ h · H a ¨. A _. . _ · - 'Q a q treatment. However, including chemotherapy, endocrine therapy, including systemic treatment, can not guarantee people are effective. Must therefore be If removed too early, or localized disease, radiotherapy, patients will lose an evaluation of treatment efficacy and determine the basis for the next step. ⑤ Do not prematurely disable effective endocrine treatment,[link widoczny dla zalogowanych], even if the patients remained stable, and should be used until the disease worse. For ≥ 6 months of stability (sD) survival of patients with complete remission (CR) and partial remission (PR) cases similar. Efficacy in stable patients over a longer period through drug, it is possible to obtain the benefits of prolonged survival. ⑥ To prevent ER (+) patients with postoperative recurrence and metastasis,[link widoczny dla zalogowanych], can be formal with 6 cycles of adjuvant chemotherapy in sufficient quantity, and then use the 5-year secondary TAM, not to the same time or alternating between the two in combination. ⑦ ER (a) is not suitable for postoperative adjuvant TAM therapy. ⑧ current standard treatment challenged in TAM,[link widoczny dla zalogowanych], the new aromatase inhibitors may replace TAM, but the former only applies to post-menopausal patients on pre-menopausal patients had to be ovariectomized, or both, with 1 per month LH Ng -RH analogues, such as goserelin. Advances in breast cancer radiation therapy center Yuzi Hao Wu Jun of China Academy of Medical Sciences Peking Union Medical Radiation Oncology, Cancer Hospital (100021) is a common female breast cancer in the United States 40 to 55 years in women, breast cancer accounts for the first cause of death. In China, the incidence of breast cancer rise. Breast Cancer is the most detailed study of various tumors, large-scale randomized controlled one of the most studied disease, has been living in a variety of cancer research in the leading position. In this paper, the study of breast cancer based on evidence-based medicine, introducing the current progress in breast cancer radiotherapy. 1 breast-conserving treatment of early breast cancer breast conserving therapy in the 70 years since the second century, the development of BU and has matured, for the beauty needs of patients and quality of life is important. Europe and other developed countries currently account for breast-conserving surgery 50%, six large prospective studies and 3 Meta analysis showed that breast-conserving surgery plus radiotherapy in local control, distant metastasis rate and survival rate with radical mastectomy There was no significant difference; conserving surgery plus radiation therapy after the second primary contralateral breast cancer and no significant increase. Breast-conserving surgery is the best indication I, II small tumors early breast cancer. However,[link widoczny dla zalogowanych], recent studies have shown that tumor volume greater than 3m in the case or part II of induction chemotherapy in locally advanced breast cancer and preoperative radiotherapy may preserve the line of mammary gland surgery. Axillary leaching
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