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 Posted: Sun 1:41, 20 Mar 2011 Post subject: tory burch outlet Metformin treatment of polycysti |
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Metformin treatment of polycystic ovary syndrome, clomiphene 60 cases
Determination of the menstrual cycle or hormone progesterone withdrawal bleeding in the first 2 - 5 days before 9 am, fasting venous blood 4ml, measured by radioimmunoassay of sex hormones 6 _1]. Treatment method in spontaneous menstruation or induce menstruation progesterone 5 days in the control group were given clomiphene citrate 50mg,[link widoczny dla zalogowanych], 1 times / d,[link widoczny dla zalogowanych], even for 5 days, treatment for 3 months. Test group first service metformin 250mg, 3 times / d, 3 months after medication,[link widoczny dla zalogowanych], according to the control group method of taking clomiphene citrate for 3 months. Observed indicators were observed ovulation rate, pregnancy rate differences. Statistical methods used test. Observed during the treatment of patients followed up for menstruation, ovulation cervical mucus of the situation, basal body temperature type, B-monitoring of ovulation. After treatment,[link widoczny dla zalogowanych], repeat the laboratory tests. The results of the experimental group 81.6% total ovulation rate, pregnancy rate was 42.1%; control group, 60.0% total ovulation rate, pregnancy rate was 21.2%,[link widoczny dla zalogowanych], the difference was statistically significant (P <0.05 .) PCOS patients to discuss the main obstacles to the follicular development FSH synergistic effect of insulin results in the granulosa cells. From the functional point of view, high insulin on reproductive dysfunction in PCOS, since gonadotropin-like effect. Thus, insulin resistance and hyperinsulinemia are considered high-islet dysfunction in PCOS reproductive base, which is the treatment of insulin resistance in PCOS patients to provide a theoretical basis for the treatment of PCOS has opened a new field. By inhibiting the intestinal absorption of metformin glucose, HGP decreased synthesis, increased muscle tissues loaded with insulin sensitivity, reducing insulin resistance caused by compensatory hyperinsulinemia. Metformin was used in 1994 the treatment of PCOS, there are a large number of studies have shown that, PCOS after metformin treatment, can improve insulin resistance and improve lipid metabolism, improve insulin sensitivity and blood levels of sex hormone binding globulin, androgen and lower blood LH levels, restored ovulation and menstrual regularity, and that its therapeutic effect is independent of weight change. PCOS patients with follicular developmental disorders raise the basic performance of a follicle larger number of options and advantages of the blocked follicle, follicular development stagnated and no ovulation occurred. Turn the current literature suggest that follicular development disorders and hyperinsulinemia on the follicular granulosa cell function within the relevant: @ PCOS patients without the mechanism of ovulation is not the pituitary or ovary itself, but mainly with the ovarian follicles of gonadotropin corresponding single sensitivity to high levels of. ② follicular gonadotropin high sensitivity, synthesis of granulosa cells may make too much estradiol (E2), FSH level to drop enough to induce other normal follicle development, which also interfere with normal follicular abnormal follicle development, dominant blocked follicle selection. In conclusion, metformin treatment of polycystic ovary syndrome is a relatively safe and effective method, with the progress of the study will be more and more sure.
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