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Two New Polyoxygenated Cyclohexenes from Uvaria kweichowensis


weenH a 3andH a 7wasobservedintheNOESYspectrumofcompound2, sothebenzoxyl-oxymethylgroupofcompound2wasdeducedtolocateatpseudo-axialposition. TheCDspectrumofcompound2exhibitedapositivecottoneffectat235.5 (+5.0, andanegativecottoneffectat218.5 (a 4.09),[link widoczny dla zalogowanych], indicatingthetwobenzoxygroupswereorientedinaclockwisemanner. Sincetheoverallrelativeconfigurationwasknown, theabsoluteconfgurationofcompound2wasestablishedas1R. 2S. 3S, 4S. Compound2isastereoisomerofpiperenolB. theabsoluteconfigurationofwhichwasreportedas1S. 2S, 3S, 4R, andthedifferenceetweenthemwereinitsconfigurationatC. 1andC. 4. AcknowledgmentsThisprojectwassupposedbytheNationalNaturalSciencesFoundationofChina (No.30472077) andtheNaturalSciencesFoundationofBeijingCity (No.7052049). WealsowanttoexpressourthankstoProfessorChap-YiDengintheInstituteofForestryofGuizhouprovinceinChinaforthecollectionofplantmateria1.1346QiangMingXUeta1.1. M. Leboeuf, A. Cave, P. K. Bhaumik, B. eta1. , Pytochemistry, 1982,21 (12), 2783.2. M. H. H. Nkunya, H. Weenen, N. J. Koyl, eta1. , Phytochem ~ try, 1987,26 (9), 2563. . 3. A. Liu, Z. M. Zou, L. Z. Xu, S. L. Yang, Cem. The destroyed, 20o3, J4 (11),[link widoczny dla zalogowanych], 1144.4. Y. H. Liao, Z. M. Zou, J. Guo, L. Z. Xu, M. Zhu, S. L. Yang, Chin. Pharm. Sci. ,[link widoczny dla zalogowanych], 2O00, 9 (4), 170.5. X. PPan, D. Q. Yu, C. H. He, J. J. ChaJ, Acta. PharmaceuticaSinica, 1997,32 (7), 530.6. J. B. Chang, R. EChen, Q. Wang,[link widoczny dla zalogowanych], PLiu, X. PPan, D. Q. Yu, ActaChemicaSinica, 2000,58 (5), 554.7. R. J. Abraham, H. Gottschalck, H. Paulsen, W. A. Thomas, Chem. Soc. , 1965,6268.8. N. Harada ~ K. Nakanishi, Am. Chem. Soc. ,[link widoczny dla zalogowanych], 1969,91,2563.9. S. C. Taneja, S. K. Koul, EPushpangadan, eta1. , Ptochemistry, 1991,30 (3), 871. Received25January, 2005