 Posted: Fri 21:48, 11 Feb 2011 Post subject: An Efficient Synthesis of Cyclopeptides Bridged wi |
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| An Efficient Synthesis of Cyclopeptides Bridged with Aliphatic-aryl Ether Bond
mtodryness. TheresidueWastrituratedwith30mLanhydrousetherandfilteredgivingpowderedproductC (297mg). Insummary, wehaveachievedthesynthesisofcycficether-linkedpeptidesonsofidsupportswithminimumsteps. Allfinalproducts (A, BandC) wereobtainedingoodoverallyields (58.9-87.1%), andcharacterizedbyAAA (exceptC) andESI. MS (Table11.Theresultsofthepresentstudyindicatedtllatthesolid.phasesynthesiswouldbean762ZheL1Ueta1.efficientwayforthepreparationofcycficcompoundenefi ~ dfromthepseudo-dilutioneffectonsolidsuppo ~. AcknowledgmentThisworkwasfinanciallysupportedbytheGrant (No.30271530) fromtheNationalNaturalScienceFoundmionofChina.WethankProfessorZeperAblizandhiscoHeaguesforprovidingmassspectraldata.andMr.NiJing-huaforprovidingAAAdata.ReferencesandNotes1.K.Burgess, D. Lim, M. B. Choussy, J. Zhu , TetrahedronLeft., 1997,38,3345.2. Y. Fleng 'Z. Ⅵ g'S. Jin, K. Burgess, Am.Chem.Soc, 1998,120,nike shox,10768.3. K. Endo,timberland boots, H. Takahashi, Heterocycles, 1999,51,337.4. GAbbenante, D. R. March, D. A. Bergman, Am.Chem.Soc., 1995,7 '10220 .5. EAdrain, M. I. Burguete,p90x workout schedule, S. VLuis, TetrahedronLett ., 1999,40,1039.6. Y. C. Chen, I. Bob, N. Mansur, A. Muhlrad, Pept.Res., 2O0o, 147.7.H.Q.Liu, H. Lin, CtJ . Tian, D.X.W bare Ig'C. Drg.Chem.20o3, 23 (  ,p90x workout calendar, 8o4.8.R.N.Zuckermann, J. M. Kerr, S. B. H. Kent, Am. Chem.Soc., 1992,114,10646.9. N. Fuiii, A. Otaka,GHD glätteisen Deutschland, O. Ikemura, Chem, Soc.Chem.Commum., 1987, (4), 274.10.TheConditionsforHPLCanalysis: Instrumenttype: Alltech426, Column: AlltimaC18, 5u (10 × 250mm), Mobilephase: bufferA: 0.05% H, 0: bufferB: 0.05% IcetoniWileisfrom0% to100% iIl15minutesataflowrateof1.0mL/min.W_avelengtll: 278am.Received12July, 2004 |
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